Protein High-Force Pulling Simulations Yield Low-Force Results

Protein High-Force Pulling Simulations Yield Low-Force Results

All-atom explicit-solvent molecular dynamics simulations are used to pull with extremely large constant force (750-3000 pN) on three small proteins. The introduction of a nondimensional timescale permits direct comparison of unfolding across all forces. A crossover force of approximately 1100 pN divides unfolding dynamics into two regimes. At higher forces, residues sequentially unfold from the...

Force fields for protein simulations.

Comparison between static maximal force and handbrake pulling force.

The measurement of maximum pulling force is important not only for specifying force limit of industrial workers but also for designing controls requiring high force. This paper presents a comparison between maximal static handbrake pulling force (FST) and force exerted during normal handbrake pulling task (FDY). These forces were measured for different handle locations and subject characteristi...

Force field bias in protein folding simulations.

Long timescale (>1 micros) molecular dynamics simulations of protein folding offer a powerful tool for understanding the atomic-scale interactions that determine a protein's folding pathway and stabilize its native state. Unfortunately, when the simulated protein fails to fold, it is often unclear whether the failure is due to a deficiency in the underlying force fields or simply a lack of suff...

طراحی سکونیرو ‏‎(force plate)‎‏

تجزیه و تحلیل گیت ‏‎(gait analysis)‎‏عبارت است از تحقیق روی راه رفتن از نظر حرکت اندامها می باشد، در این بررسی می توان مواردی نظیر کنترل موقعیت، سینتیک و سینماتیک بدن ، کنترل بدن و کنترل عصبی را در نظر داشت. اینگونه تحقیقات در ارتوپدی ، بیومکانیک ورزش و عصب شناسی و کاربرد دارند. پارامترهای مهم در اینگونه تحقیقات عبارت از نیرو ، ممان ، سرعت ، مصرف انرژی و فشار کف پا می باشند. سه روش برای اندازه ...